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Although the investigators adjusted for such things as age, sex, and smoking status, "there are obviously other factors that can increase the risk of cardiovascular disease that weren't measured." Still, he said that "this is the first real data that we're seeing associating e-cigarette use with hard cardiovascular events." And the study raises concerns "that it may be e-cigarette smoke as well as combustible tobacco smoke that may increase risk." Goldstein later told Medscape Medical News that because the use of these products "is really exploding," the results on their health effects are especially important

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